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SIR2 was the first identified evolutionarily conserved gene which had been implicated in the expansion of lifespan.
The cause of the proliferation defect is uncertain, but we note that Vangl2 has been implicated in the expansion of muscle (4) and neural (3) stem cells.
10 IL-2 stimulates T-cell growth, but has also been implicated in the expansion of regulatory T-cells that express CTLA-4.
Wild birds have been implicated in the expansion of highly pathogenic avian influenza virus (H5N1) outbreaks across Asia, the Middle East, Europe, and Africa (in addition to traditional transmission by infected poultry, contaminated equipment, and people).
In this study we have used a gene expression microarray and a subsequent bioinformatic approach to identify new molecular mechanisms and pathways implicated in the expansion of pancreatic β-cells in the context of insulin resistance.
In addition to the examples discussed above, oxidative stress and the relative availability of 5′-end processing activities have also been implicated in the expansion of triplet repeats in Huntington disease (Goula et al, 2009; Kovtun et al, 2007).
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Replication, repair, and transcription are implicated in the expansion process, but their relative contributions are yet to be distinguished.
Furthermore, we demonstrate that both the single-strand exonucleases, ExoI and RecJ, participate in controlling the frequency of expansions, consistent with there being both 3′ and 5′ ends implicated in the formation of the expansion products.
The finding that the Tregs enriched in SCC FAK-WT tumors were likely recruited into SCC FAK-WT tumors led us to consider a potential role for Ccl5 that has been implicated in the recruitment and expansion of CD4+FoxP3+CD25+ Tregs (Tan et al., 2009), via the paracrine signaling axis that we identified.
Alterations of PRKG1 have been implicated in the origin of clonal expansion of primary tumors from breast cancers [52], hepatocellular carcinomas [53] and uterine leiomyomas [54].
Slipped-out (CAG) n · CTG) n repeats have been implicated in the pathogenesis of triplet repeat expansion diseases such as Huntington's disease and several others.
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