Sentence examples for implicated in the establishment of from inspiring English sources

This indicates that the PrDs in these proteins may be implicated in the establishment of persistent viral infections and affect the adaptive immune response.

Poised enhancers marked by H3K27me3 in pluripotent stem cells have been implicated in the establishment of somatic expression programs during embryonic stem cell (ESC) differentiation.

Undoubtedly lipidomics has allowed tremendous advances in understanding and determining the true importance of lipids and FAs in many physiological and molecular mechanisms implicated in the establishment of healthy or diseased status.

Using cell based assays they have been implicated in the establishment of cell polarity, cell-shape change, cell migration, phagocytosis, secretion, cell-cycle progression, cytokinesis and transcription [1].

Signaling by TGFβ family members, notably Nodal [34] and BMP4 [29], have been implicated in the establishment of the primitive streak and formation of mesoderm during mouse gastrulation.

In vertebrate and C. elegans studies, Wnts have been implicated in the establishment of polarity, but only one study in Drosophila suggested a role for Wg in PCP[14].

One of the molecular mechanisms that has been implicated in the establishment and maintenance of self-tolerance and suppression of the development of autoreactive immune cells is ubiquitination (Fig 4).

Astrocytes have also been implicated in the establishment and growth of melanoma brain metastasis by secretion of IL-23, which induces neuroinflammatory changes and repair [ 95].

Furthermore, a number of inflammatory mediators are implicated in the establishment and progression of arthritis, including proinflammatory cytokines such as tumor necrosis factor alpha (TNFα) and interleukin (IL -6 and IL -6 [ 2, 3].

In the context of autoimmunity, both BAFF and APRIL are implicated in the establishment and/or maintenance of autoimmune disease.

A number of different mechanisms (for example, DNA methylation, chromatin modification and expression of large non-coding RNAs) have been implicated in the establishment and maintenance of genomic imprinting and a key role is played by imprinting control centres (ICs), which may regulate the imprinting of several genes [ 1].