By establishing mouse models with a targeted mutation in GDF1, researchers have shown that GDF1 is implicated in the establishment of left right asymmetry.
In summary, our study supports an important role for the country of origin, which, together with environmental conditions, is likely to be of importance in influencing the exposure of individuals to KSHV, and may also be implicated in establishing the risk for the development of CKS.
The report goes on to suggest that the other allegations against Putin over the years, for example that he was implicated in the murder of the journalist Anna Politkovskaya, "establish a pattern of events, which is of contextual importance to the circumstances of Mr Litvinenko's death".
LpnE is implicated in the ability of L. pneumophila to establish infection and/or manipulate host cell trafficking events, and its sel-1 like repeats, that interact with proteins containing Ig-like domares, are necessary for host cell invasion [69].
V-ATPases are strongly implicated in the alkalinization of the midgut pH by establishing a proton motive force by transporting proton across membranes leading to a pH gradient and transmembrane voltage [ 59- 61].
However, TPR repeat regions have been implicated in the ability of L. pneumophila to efficiently establish infection and/or to manipulate host cell trafficking event [37].
DVL proteins are implicated in establishing the asymmetric cortical domains of PCP proteins [17], and have also been shown to be required for proper basal body and therefore cilia localization [32].
It has been well established that myostatin is implicated in the induction of muscle cachexia.
Disturbances in mineral and bone metabolism well established in osteoporosis have been implicated in the pathogenesis of CVD.
It was therefore important to establish which of these combinations might be implicated in the repression of INK4a in human fibroblasts.
