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Another factor implicated in the differentiation of myofibroblasts is Thy-1, a cell surface glycoprotein, which is differentially expressed by fibroblasts [ 15].
Ether lipids have also been implicated in the differentiation of other cell types.
The primary reason for such a selection stems from the fact that the role of IL-12 has been implicated in the differentiation of Th-0 cells.
Recently, IL-6 has also been implicated in the differentiation of specific CD4+ T cell subsets.
In particular, it has been implicated in the differentiation of hematopoietic cell lines, myoblasts, neuronal cells and interfollicular keratinocytes.
The FN-mimics RGD and PHSRN have both been implicated in the differentiation of cells toward the endothelial lineage [ 122].
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Of those, miR-155 has been implicated in the differentiation and activation of cells of both the adaptive and the innate immune systems [ 4].
Indeed, DRIL1 was first described as a regulator of IgH expression [6] and our data are now showing that DRIL1 might also control the expression of other key genes implicated in the differentiation and activation of lymphocytes.
Altogether, these findings indicate that G-CSF in vivo is an inducer of IL-10, which is implicated in the differentiation and function of tolerogenic DC 34 and Tr1 cells 35.
In mammals, miRNA-122 has been shown to be implicated in the differentiation and maintenance of the hepatic phenotype [ 5- 8], and the regulation of metabolic liver functions, especially lipid metabolism.
Thus, our data suggest that Smed-mll1/2 is implicated in the differentiation or maintenance of the ventral cilia and might have a role in protonephridia development among other processes.
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