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Lrp4 has been implicated in the activity of both Bmp [26], [27] and Wnt [28], [29] signaling and both of these pathways play roles in normal branching morphogenesis.
The finding of MBP binding was surprising, since classic MBP itself is required for central nervous system myelination and has not been implicated in the activity of SOCCs.
This conclusion was further confirmed when we used the baculovirus expression system, which allowed for precise control of the expression (i.e. amount) of the different proteins implicated in the activity of the cyclin E and Cdk2 complexes.
To more systematically assess the connections between these different observed states and transcriptional repression, we applied machine learning to analyze features that may be implicated in the activity of Hairy.
These modules occur in mucin 3, 4, 12, and 17, meprin 1α and 1β, and interphotoreceptor matrix proteoglycan 2. Only one of these proteins, mucin 4, has been directly implicated in the activity of the ErbB receptor family.
Consequently, the observation that NF- κB p50 and p65 translocate to the nucleus in response to IP6 in PC3 cells led us to ask whether the modulation of NF- κB-mediated transcription was implicated in the activity of IP6 in PC3 cells.
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He is permitted visits not just with his lawyer but also with members of his family, many of whom have been implicated in the activities of his cartel.
Recently the histone H3-K9 demethylases Jmjd1a and Jmjd2c have been shown to be targets of Oct4 and are implicated in the activities of the Sox2-Oct4-Nanog network and the maintenance of pluripotency-related gene expression [26].
106 Recent work has demonstrated that CRH application triggers N-methyl d-aspartate receptor/calpain–downstreamdownstreamechanismsms 108 that have been also implicated in the activity-dependent down-regulation of KCC2.
In addition, non-nuclear targets, such as the mitochondrion and the cell surface, have also been implicated in the antineoplastic activity of some ruthenium complexes.
Covalent interactions between antibody combining site residues and substrates have been implicated in the catalytic activity of abzymes elicited by design or occurring naturally in autoimmune disease.
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