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The IgLONs are implicated in synaptogenesis.
Interestingly, the chromosomal region containing the protocadherin-α, -β, and -γ (Pcdh) gene families implicated in synaptogenesis show the highest differential response to maternal care.
This region contains the Syn3 gene, which encodes Synapsin III (see ). Synapsins have been implicated in synaptogenesis and in the modulation of neurotransmitter release [ 37].
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The latter possibility is suggested by the downregulation of both strands of serum miR-132, which has repeatedly been implicated in neuronal development and synaptogenesis [ 36].
Proteins were selected if they are structural components of synapses or if they are implicated in the dynamics of neurogenesis and synaptogenesis (table 4).
Gdh encodes a nuclear-encoded mitochondrial enzyme with a role in utilization of metabolite pools for energy production [ 35]. gli encodes a transmembrane protein transiently expressed in peripheral glia whose loss of function has been implicated in defects in axonal guidance and synaptogenesis [ 35].
Of the 45 genes of the App-Runx1 region that were referenced on chips, 33 were found to be downregulated, including App, which has been implicated in many neuronal processes, such as synaptogenesis (Wang et al., 2009), neural plasticity and memory (Turner et al., 2003).
The PI3-K/Akt pathway has been implicated in promoting neuronal survival, proliferation and differentiation, synaptogenesis as well as translocation of VGCCs to the plasma membrane.
In addition, mTOR has been recently implicated in the regulation of dendritic spine morphology, synaptogenesis and synaptic plasticity.
Synapsins constitute a multigene family of neuron-specific phosphoproteins (SYN1-3) present in the majority of synapses where they are implicated in the regulation of neurotransmitter release and synaptogenesis.
In particular, the heavily glycosylated NMJ synaptomatrix plays crucial roles in synaptogenesis during normal development, and its disruption is implicated in numerous heritable disease states (Dani and Broadie, 2012).
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