"We're obviously very concerned any time the state board is implicated in not serving children well," Mr. Gamble said.
On the downside, dopamine has been implicated in addiction, serving as a flashing neon "pleasure" sign that keeps the addict coming back for more.
This approach has been useful for ciliopathies, where almost 2,500 genes that are implicated in ciliary function can serve as potential candidates [ 58].
There were additional upregulated genes in the reproductive SE that have not previously been directly implicated in auditory function but still serve as important candidates for consideration and future validation.
However, both studies identified CNVs at several loci already implicated in GWAS, which serves as an effective positive control [ 32, 88, 89].
Altered lipid composition in both plasma and liver has been shown in patients with NAFLD and NASH and hence has been implicated in triggering inflammation and serving as endogenous danger signals [15,16].
In addition to identifying neurons that have been already empirically implicated in different functions (which serve as a verification of our method), we also predict several neurons which can be potentially crucial for certain, as yet unidentified, functions.
The SH3 domains of multiple endocytic proteins have been recently implicated in binding ubiquitin, which serves as a signal for diverse cellular processes including protein destruction [ 45].
The prosecutors' recommendation for prison time in the case of Ms. Huffman, among the best-known of 33 parents charged in what the Justice Department has said is its largest-ever college admissions prosecution, offers insight into a question that has lingered over the case: Will some of the wealthy and well-connected parents implicated in the scandal end up serving time?
