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Recently, PGE2 has been implicated in promotion of EMT in vitro[ 8].
26 Recently, EP4 has been implicated in promotion of the SLC phenotype in breast cancer cells.
Despite its role in differentiation, NURR1 has been implicated in promotion of cancer cell proliferation.
IL-6 has further been implicated in promotion of tumour growth, invasion and metastasis, and the development of drug resistance (Kato et al, 1998; Esper and Harb, 2005).
Research has shown that EVs play a role in a variety of biological processes including immunity, bone formation and recently they have been implicated in promotion of a metastatic phenotype.
Both cyclin E and c-Myc contribute to the transition of cells from G1 to S phase (Wang et al, 2008; Malumbres and Barbacid, 2009) and have recently been implicated in promotion of caspase-dependent apoptosis subsequent to S-phase arrest induced by DNA damage or inhibition of DNA synthesis in tumour cells (Mazumder et al, 2000; Leonce et al, 2001; Lu et al, 2009; Sankar et al, 2009).
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The fact that there is an increase in cell proliferation at the end of the exercise period in both running groups, and that the majority of newborn neurons die by programmed cell death within the first week of generation [3], suggests that the PI3K-Akt signaling pathway is implicated in the promotion of survival of newborn cells following exercise by inactivating proapoptotic proteins.
Moreover, Sirt1 has been implicated in the promotion of tumorigenesis and development of drug resistance.
In this respect, we note that DNA hypomethylation (DNhpom) at CpG dinucleotides (cytosine nucleotide found adjacent to guanine nucleotide) is an example of an epigenetic process implicated in the promotion of carcinogenesis (Ehrlich, 2005), as well as in the activation of globin γ-chain gene expression (Atweh et al, 2003; Lavelle, 2004).
As a central differentiation process, EMT allows for the remodeling of tissues during the early stages of embryogenesis, and is implicated in the promotion of tumor cell invasion and metastasis.
Notch signaling has been implicated in the promotion of SM at the expense of striated muscle development from bipotent progenitors resident in the lateral DM [ 14].
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