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The N-methyl-d-aspartate receptor (NMDAR) has been strongly implicated in mechanisms of persistent pain states.
Alpha Synuclein (α-Syn) is a protein implicated in mechanisms of neuronal degeneration in Parkinson's disease (PD).
A number of amyloid diseases involve deposition of extracellular protein aggregates, which are implicated in mechanisms of cell damage and death.
Urokinase that also binds the RGG domain of nucleolin is implicated in mechanisms regulating pericellular proteolysis, cell-surface adhesion, and mitogenesis [21], [24].
We have focused on the canonical Wnt pathway, which has an established role in developmental processes, but has recently been implicated in mechanisms of neurodegeneration/neuroprotection in the adult brain [25] [27].
Laminin-1 that induces differentiation of cells binds surface nucleolin, while urokinase that is implicated in mechanisms regulating pericellular proteolysis, cell-surface adhesion, and mitogenesis binds and is co-internalized with surface nucleolin [14], [18], [19].
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It is known that Granzyme A (GzmA) and granzyme B (GzmB) are implicated in these mechanisms.
Proinflammatory cytokines have been implicated in the mechanisms that are responsible for brain injury in cases of intrauterine infection.
The enzymes have been implicated in signalling mechanisms controlling cell proliferation and programmed cell death and in metastasis, immune responses, and Golgi restructuring and function.
Activation of signaling pathways such as GSK3β and CDK5 has been implicated in the mechanisms of HIV neurotoxicity; however, the downstream mediators of these effects are unclear.
miR also have been implicated in defense mechanisms against viral infections, where they may contribute to controlling viral infections.
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