Sentence examples for implicated in malignancy from inspiring English sources
PCSK1 may be implicated in malignancy [40].
Deregulated translation initiation through elevated eIF4E levels and increased eIF4F activity has been repeatedly implicated in malignancy through the altered translation of pro-survival and pro-growth encoding mRNAs that contribute to oncogenesis [31], [32], angiogenesis [17], and chemoresistance [33].
Of all the eIFs, eIF4E is the most strongly implicated in malignancy.
Several of these genes have been implicated in malignancy and are of particular interest given the increased rate of malignancy previously identified in Plk4 heterozygous mice.
CENP-F has been implicated in malignancy [ 31, 32], and its expression is correlated with tumor size in node-negative breast cancer [ 33].
Most of these factors have complex mRNA 5′ UTRs and all have been implicated in malignancy (Rosenwald et al, 1999; Berkel et al, 2001).
It is also known to be involved in hematopoietic development [44] [47], to be expressed by PBMC [48] and neutrophils [33] and to be implicated in malignancies such as ovarian cancer [49], hepatocellular carcinoma [50] and bladder cancer [51].
PTCH2 (OMIM 603673, Locus Link 8643), the human homologue of Drosophila patched-hedgehog, has been implicated in malignancies such as medulloblastoma and basal cell carcinoma [ 19].
This full-length form is implicated in malignancies where ALK promotes tumorigenesis via activation by autocrine and paracrine growth-promoting loops involving the putative endogenous ALK ligands PTN (pleiotrophin) and MK (midkine) [ 22].
LGR5 is pivotal to oral cavity development and is implicated in epithelial malignancy whereby stimulation of LGR5 potentiates canonical Wnt signaling.
Some of the phosphoproteins identified in this study have been previously implicated in cancer malignancy such as Mcm2 and adenylyl cyclase associated protein (CAP1), while little information is available on some of the other potential targets including small acidic protein (Table 2).
