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Emerging evidences suggest that nucleolin expressed on the cell surface is implicated in growth of tumor cells and angiogenesis.
Several reports have suggested that cell-surface nucleolin is implicated in growth of tumor cells and angiogenesis [2], [15], [16].
There are increasing evidences that nucleolin expression on the cell surface is implicated in growth of tumor cells.
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The peripheral benzodiazepine receptor (PBR) has been implicated in growth control of various tumour models.
We focused in this work on the role of the RARα1 isoform which, directly, or through RARβ expression, has been implicated in growth suppression of normal and cancerous breast cells in vitro [ 2, 6, 7].
β-catenin is implicated in growth and metastasis of various cancers, including NSCLC, by modulating both cell adhesion and gene transcription.
Prolactin (PRL) is a peptide hormone implicated in growth and differentiation of breast epithelial cells (Das and Vonderhaar, 1997; Maus et al, 1999; Vonderhaar, 1999; Clevenger et al, 2003).
Indeed, TRPS1 is a zinc finger transcription factor implicated in growth and trichosis, some of its variants being associated with trichorhinophalangeal syndromes [ 54, 55].
Glycogen synthase kinase 3 (GSK-3) signalling is implicated in the growth of the heart during development and in response to stress.
Of note, the expression of miRNAs miR-520c and miR-373 is known to characterize stem cells and in terms of molecular oncology has been implicated in invasive growth of epithelial cells in vitro and in vivo thus allowing to delineate a distinct molecular subtype of thyroid adenomas.
MMPs are a family of zinc-dependent enzymes, which are implicated in the growth of primary and secondary tumours (Cox et al, 1999).
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