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SCUBE2 is a multidomain, secreted glycoprotein that was first implicated in functioning upstream of hedgehog signaling in zebrafish, but has since been shown to also play a pivotal role in human tumorigenesis [ 52, 53].
Ptc2p dephosphorylates Hog1p as well as Cdc28p, and is also implicated in functioning with proteins such as RAD53 to regulate DNA damage checkpoint pathways (Cheng et al. 1999; Marsolier et al. 2000; Young et al. 2002).
Other factors, such as AP-1 and NFAT family members, which are activated downstream of the T cell receptor (TCR), have been implicated in functioning as general acting pioneer factors at enhancers in Th1 and Th2 cells [ 55], Th17 cells [ 56] and in Tregs [ 57].
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Residue conservation is usually implicated in function.
It is implicated in functions as diverse as development of the anterior portion of the brain; formation of digits; the organization of the brain, skeleton, gastrointestinal tract, lungs, eyes, teeth, taste buds, musculature; as well as other craniofacial structures.
Non-catalytic PGRPs have been implicated in functions as diverse as immune receptors, regulators and effectors [4].
Residues implicated in function are conserved in both IscU and IscS proteins.
It was implicated in functions related to translation elongation such as decoding accuracy and mRNA unwinding.
eArabidopsis MYBs implicated in functions besides SCW regulation with higher sequence identity to proteins from the other species compared with the At SCW MYBs in the same clade.
In the cell nucleus, monomeric globular (G) actin has been implicated in functions such as chromatin remodeling and transcription (Belin & Mullins, 2013), but it is unclear what role is played by filamentous (F) actin.
NetrinG NGL interactions have been implicated in functions at each of these levels (Lin et al, 2003; Kim et al, 2006; Nishimura-Akiyoshi et al, 2007), culminating in trans-synaptic adhesion and synaptogenesis (Kim et al, 2006).
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