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In addition, sNPF is implicated in feeding and growth in Drosophila [42], [43] and food search in mosquitoes [57] and tachykinins display weak diuretic action on renal tubules of moth and locust [49], [50].
They were initially implicated in feeding behavior and sleep\wake cycles (de Lecea et al., 1998; Sakurai et al., 1998).
Initially implicated in feeding behavior, they were also found to regulate cortical arousal and the sleep-waking cycle.
Light pulses (both short and long) also regulated genes implicated in feeding as well as different physiological processes like metabolism, transport, immunity and protease digestions.
For example, Gh gene expression in the brain correlates with increased food consumption and body weight in mice [ 13, 14] and has been implicated in feeding behavior and energy homeostasis [ 35, 14].
Interestingly, the subesophageal ganglion region has been implicated in feeding and taste responses, as gustatory sensory neurons and hugin neurons (that are known to modulate feeding behavior) project to this region [21].
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RNAi technology has great potential to advance the field of tick biology since it provides a direct method to systematically identify genes involved in variety of pathways implicated in tick feeding or disease transmission to vertebrate hosts.
Orexin A and B are recently identified as peptides that are derived from the same precursor and their expression is highly specifically localized in neurons located in the lateral hypothalamic area, a region implicated in the feeding behaviour.
Neuropeptide F, the Drosophila ortholog of Neuropeptide Y, has been implicated in control of feeding [ 19] and motivational behavior [ 20] and is an excellent candidate for modulating sleep-feeding interactions.
The hug gene has been implicated in regulation of feeding behavior in relation to chemosensory and nutritional signals [35] and CAPA-PVKs display diuretic activity on Malpighian tubules [34].
Orexin has been implicated in arousal and feeding behaviour, but more recently also in the mesolimbic reward pathway.
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