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Regions of the PFC have been implicated in experience [30] and observation [31] of negative mood, and higher activity in response to negative than positive images has been evidenced in regions of the right ventrolateral PFC specifically [32].
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Second, using functional magnetic resonance imaging (fMRI), we showed that the anterior cingulate cortex and the left anterior insula, two cortical structures typically involved in vicarious feelings of others' pain, are also strongly implicated in experiencing the 'social pain' for others' flaws and pratfalls.
Transcription factors, including NF-κB, are implicated in experience-based synaptic regulation, and mouse models involving altered NF-κB activity have revealed the importance of the various forms of this transcription factor in learning and memory (reviewed in [ 26]).
Alpha activity directly before pain onset has been implicated in pain experience with higher prestimulus alpha associated with lower reported pain.
Furthermore, even if the treatment side effects are deemed acceptable by both patient and clinician alike bearing in mind that full informed consent is not possible—I use phenomenology to highlight how informed consent procedures are not sufficiently nuanced to appreciate how side effects are implicated in the experience of suffering.
Indeed, precuneus has been mainly implicated in subjective experience and conscious self-representation [ 31, 41].
The middle anterior cingulate cortex has been implicated in the experience of agency in healthy subjects (Tomlin et al., 2006) and in misattribution of own recorded speech as others' speech in schizophrenic subjects (Allen et al., 2007) and the right posterior temporal lobe has been implicated in the experience of agency (Tankersley et al., 2007).
Dopaminergic neurotransmission is implicated in the experience of reward which in turn is likely to be a crucial agent in the take-up and maintenance of exercise behavior [ 17].
By comparison, the more personal interaction within interviews is thought to evoke a 'moral dilemma' wherein participants' identities become implicated in the experience of disadvantage [ 16, 20, 4, 23, 11, 19].
Augmented reality (AR) – the idea that real-world user behavior, hardware and devices could be implicated in fictional experiences – dates back to the mid to late 1990s.
These channels seem like pleasant versions of the famous C-fibers implicated in pain experiences.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com