"Low-calcium intakes have been implicated in disorders such as premenstrual syndrome, polycystic ovary syndrome, pre-eclampsia and mood disorders".
S1P has been implicated in disorders such as cancer and inflammatory diseases, and several agonists and antagonists have been developed and are in clinical trials that target S1PR1 (Kunkel et al., 2013).
Besides, BDNF has complex interactions with sympathetic neurons[12], [13] and has been implicated in disorders of vascular tone dysregulation [14].
Being a key process in learning and adaptive knowledge, problems in reconsolidation have been implicated in disorders such as Post Traumatic Stress disorder (PTSD), Obsessive Compulsive disorder (OCD), and even addiction.
Deregulation of IL-6 expression is implicated in disorders of bone homeostasis such as osteoporosis and osteopetrosis.
NE signaling is also implicated in disorders of anxiety, depression and cognition (Beane and Marrocco, 2004; Pliszka, 2005; Ressler and Nemeroff, 1999).
Decreased thalamic activity has also been implicated in disorders of consciousness (Lutkenhoff et al., 2013), and may be a potent mechanism for inducing decreased arousal (Schiff, 2008).
Interestingly, similar local protein synthesis pathways were recently implicated in disorders with high comorbidity with epilepsy, such as Fragile X and autism.
RSK proteins have been implicated in disorders of cognition and behavior, and mutations in RSK2 lead to Coffin-Lowry syndrome, an X-linked dominant genetic disorder that causes severe mental problems [ 82].
The basic association between lesion probability and nodal degree demonstrated for the DTI connectome globally was also evident for frontal and temporal cortical subsets of the connectome, indicating that both cortical and subcortical hubs are implicated in disorders.
