In contrast to past trial-and-error discovery, we are starting to see designer drugs that target known sites on molecules implicated in disease.
The information will be pored over by thousands of researchers, who will analyse and interpret the DNA variations between people in a bid to work out which ones are implicated in disease.
And the common, cell-adhesion variant, he adds, suggests that cell adhesion is "implicated in disease".
It may also be a good therapeutic strategy for selective targeting of a gene product implicated in disease pathogenesis.
We explore the potential role for microRNAs as therapeutic tools to modulate target RNA sequences implicated in disease states.
Extracellular Nef which has been implicated in disease progression and development of AIDS induces IL-10, a potent immunosuppressive cytokine, in vitro.
A lack of bony constraints and laxity of the supporting ligaments, particularly the "beak" ligament is consistently implicated in disease progression.
This information has the potential of elucidating gene regulation mechanisms and identifying genes implicated in disease or perfecting industrially important high-performance strains.
Heparan sulfate (HS) proteoglycans at cell surfaces and in the extracellular matrix of most animal tissues are essential in development and homeostasis, and variously implicated in disease processes.
Together, these studies reveal the molecular basis for JMJD2 site specificity and provide a framework for structure-based design of selective inhibitors of JMJD2 KDMs implicated in disease.
qPXO79/112/341_12-1 conthreed three cysteine-rich receptor-like protein kinases, a gene family previously implicated in disease resistance through activation of hypersensitive response upon pathogen recognition (Chen et al. 2004).
