Given that the RAS-MAPK pathway is also implicated in cancer, developing inhibitors of this pathway has been a major focus of many pharmaceutical companies, and clinical trials to test them in a subset of cancer patients are currently underway.
As a neuronal guidance molecule, netrin-1 has been implicated in the developing brain Previous studies have found high expression levels of netrin-1 in the intestine, including in patients with inflammatory bowel disease (IBD) Netrin-1 has been implicated in immune functions At present, the functional role of netrin-1 in IBD is unknown.
For instance, in a broad review article on CVD (41), Yusuf and co-authors strongly implicate urbanization in developing societies.
To clarify the molecular mechanisms of Spn-F retention we focused on Jvl, which is reported to interact with Spn-F and has been implicated in IKKε polarization in developing oocytes (Dubin-Bar et al., 2011; Amsalem et al., 2013).
Micro-organisms implicated in NNS have developed increased drug resistance to commonly used antibiotics and thus making treatment extremely difficult [ 11].
ZBTB20 has an important role in the developing hippocampus, a region previously implicated in the development of MDD.
Finally, vitamin D deficiency has been implicated in the likelihood of developing a variety of autoimmune diseases including insulin dependent diabetes mellitus, rheumatoid arthritis, experimental autoimmune encephalomyelitis (EAE), and inflammatory bowel disease [53], [54], [57].
38, 41 This may be analogous to the overlapping pathogenetic pathways underlying obesity and type 2 diabetes, where the fat mass and obesity-associated gene has been implicated in the propensity to developing both obesity and diabetes.
Cases and controls were first compared with regard to the distribution profile of clinical aspects potentially implicated in the risk of developing cancer and that could interfere as confounding factors on the analysis of the risk associated to PTGS2 SNPs (Table 4).
