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Such policies may be directly implicated in decreasing the probability of failure to a large degree while also decreasing slightly the probability of higher success.
The IL-6 has been shown to be increased in rheumatoid arthritis, a chronic inflammatory disease, where it has been implicated in decreasing G protein-coupled receptor kinases (GRKs) in peripheral blood mononuclear cells.
30 In addition hypoxia has been implicated in decreasing the activity of the mismatch repair pathway.
Metformin and proton pump inhibitors have been implicated in decreasing levels of vitamin B12 independently.
58– 60 Simian immunodeficiency virus infection of macaques was also implicated in decreasing bone mineral density.
Furthermore, n-3 LCPUFAs have been implicated in decreasing the severity of secondary cancer complications including cancer cachexia.
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Sorted rat beta-cells were exposed to TNF-alpha in combination with IL-1beta and IFN-gamma (cytomix), known to be cytotoxic towards beta-cells and believed to be implicated in decreased beta-cell function and mass in diabetic state.
Gasier, HG, Demchenko, IT, Tatro, LG, and Piantadosi, CA. "S-nitrosylation of GAD65 is implicated in decreased GAD activity and oxygen-induced seizures". Neuroscience letters 653 (July 2017): 283-287.
Increased expression of anti-apoptotic factors such as Bcl-XL, which affects the intrinsic pathway, have been implicated in decreased apoptosis.
The proper functioning of this complex tissue involves adaptation to a host of cellular and environmental stressors over time, and cumulative long-term detrimental effects of oxidative stress have been implicated in decreased aqueous humor outflow.
While IL-1β and IL-6 have been strongly implicated in decreased NSPC proliferation and neurogenesis [18], [19], others like TNF-α exert dual effects depending on the receptor types involved.
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