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BAFF, as well as its close family member APRIL, have also been implicated in class switch recombination.
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The profound downregulation of HLA-DR in ITD+ DC subsets might be implicated in defective class II antigen presentation leading to dysregulation of these APCs.
Although several cerebellar malformation genes have been identified, no gene directly involved in the formation or function of the Isthmic Organizer had previously been implicated in this class of birth defect, suggesting that Isthmic Organizer disorders might not be compatible with survival in humans.
In this pilot study, we included the 267 genes because genetic heterogeneity exists in all disease classes and several genes are implicated in different classes (e.g. LMNA or DNM2).
As APRIL-TACI signaling has been widely implicated in T-independent IgA class switching [12] we next investigated a role for this pathway in absence of CD40.
Since ubiquitination has been implicated in the degradation of class II MHC molecules [5], we wanted to address whether the degradation of class II MHC molecules is altered in I-Aβ-K225R-EGFP mice.
In a typical worker ant, more than 10 organs have been implicated in producing just one class of chemical signal.
In addition, regions implicated in the production of class II bacteriocins were revealed in the vaginal isolates.
This isoform is also implicated in major histocompatibility complex class II presentation of cytoplasmic antigens [ 17] as well as in the regulation of T-cell responses [ 18].
Transcripts that either belonged to a functional class implicated in cartilage development or exhibited marked changes with DEX treatment were chosen.
The exact role of these proteins in fungal growth is not known, but Mlc1 is a myosin light chain, implicated in controlling secretory motor class V myosin Myo2p in budding yeast (Stevens and Davis, 1998; Wagner et al., 2002).
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