The predictive protein interactome analysis implicated genes in addition to the ones revealed by the microarray studies, such as Drp1 and AKAP10.
Our findings implicate that, in addition to the expression level of GHR, the cellular concentration of free Jak2 is a major factor that regulates the number of GHRs at the cell surface.
Recent studies implicate that in addition to the tau protein expression level and turnover aberrant posttranslational modifications of tau protein such as phosphorylation [8], O-GlcNAc glycosylation [9] and oxidation [10] are involved in initiating tau aggregation.
These changes implicate that in addition to the membrane microdomain organization at the protein and lipid levels, the cytoskeletal integrity and the interaction between plasma membrane and cytoskeleton are also altered by SMase.
If, however, significant variability in PD-1 expression were to exist among clonotypes with identical epitope specificity, then factors specific to particular clonotypes of responding cells would be implicated as determinants in addition to the level of antigen presentation.
A number of genome-wide association studies (GWAS) that have been conducted in humans, 80 mice, 81– 83 and cattle 84, 85 have implicated multiple genes, in addition to PRNP, that confer varying degrees of susceptibility, to a variety of prion disease.
"The government should establish more effective administrative sanctions on professional enablers by encouraging professional bodies to withdraw professional licences from those implicated in such cases, in addition to prosecuting those who are personally involved," the report said.
Vav, another RhoGEF composed of several domains that have been implicated in protein protein interactions in addition to the DH and PH domains, has been shown to be broadly active with several Rho GTPases, such as Rac, RhoA, and Cdc42.
Deflation of Context A not only decreased behavioral control by the CS in the AAA condition, but increased it in the AAC condition, thereby implicating a comparator process in addition to associative summation between the CS and test context.
In this respect, our findings are consistent with previous studies implicating the MDA5/IPS-1 pathway in addition to TLR-mediated sensing for optimal cytokine responses to MVA infection [37], [38].
