Sentence examples for implicated in a cascade from inspiring English sources
To further simulate a paternal genome, the team used immature oocytes that carried a mutation that disables a gene implicated in a cascade of imprinting events thought to derail parthenote development.
Vinculin is implicated in a signaling cascade involving paxillin binding and subsequent inactivation of the extracellular signal-regulated kinase (ERK) and p21 GTPase activated kinase (PAK) (17– 17).
PP2A has been implicated in a multitude of signalling cascades that control cell proliferation, division, differentiation, apoptosis, metabolism, adhesion and migration and is thought to modulate the activity of over 30 different kinases [reviewed in (4)].
The c-Jun NH(2 -terminal kinase (JNK) signaling cascade has been implicated in a wide range of diseases, including cancer.
As well as its established role in membrane structure, many studies have now shown that ceramide is a key second messenger, activating a number of intracellular signalling cascades that are implicated in a wide range of cellular functions such as proliferation, differentiation, necrosis and apoptosis [ 2- 4].
Constitutive activation of the EPO/JAK2 signaling cascade has recently been implicated in a variety of myeloproliferative disorders including polycythemia vera, essential thrombocythemia and myelofibrosis.
Communication practices of healthcare professionals have been strongly implicated in the cascade of events that unfold into poor outcomes for surgical patients.
These secreted proteases are implicated in proteolytic cascade pathways resulting to extended cleavage of ECM components.
Among chemokines implicated in this cascade; SDF-1α/CXCR4 regulates organ specific colonization of metastatic tumor cells [ 3– 6].
Defects in pathways essential for mitotic regulation are likely to be implicated in the cascade of events leading to aneuploidy and neoplasia.
Thus, elevated activity and/or expression of iNOS, COX-2, MMP-9, IL-1β and TNF-α in brain cells have been implicated in the cascade of events leading to neurodegenerative diseases.
