The expression of IL22ra2 has been demonstrated to differ between the strains implicating difference in regulatory regions [ 31].
The heterogeneous results may implicate differences in surveillance and healthcare systems.
The distinct phenotypes displayed by SLHCC and NHCC implicate differences in biology.
A biological explanation implicating differences in disease severity is possible, but inadequate immunosuppression in our patients is also highly probable.
Finally, the 2008 wildfire occurred June to July while the 2011 fire began during an unseasonably warm May, possibly implicating differences in environmental conditions.
However, some patients suffer from unexpectedly early recurrence among those who underwent curative surgery even in Stage II cancer, implicating differences in biological characteristics.
Also, in this case we found a high B7.1/2-costimulatory requirement, which further indicates that the degree of expansion is comparable between the LCMV versus MCMV groups, and that possible differences in expansion is not implicated in differences in costimulation redundancy.
For example, GADA has been implicated in differences in peripheral nerve function, independent of GADA related differences in glycemic control [76].
Gender has also been implicated in differences in methylation [ 15, 54, 55], but we found no significant difference in methylation of either gene in any group associated with gender, and when controlling for gender, obtained no difference in our findings.
Undeniably, the results obtained using microarrays need to be validated with other techniques (for example in situ hybridization and immunohistochemistry should permit a better definition of specific cell types implicated in differences in gene expression).
