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Although the genes that were determined to have differential methylation patterns in polyps by MeDIP-seq were not significantly associated with the TGF-β, NOTCH, and RTK signaling pathways, the Wnt/β-catenin pathway was identified as one of the most significant canonical pathways implicated based on methylation changes in the polyps (ranked 11th).
We used the MetaCore transfactor analysis tool to determine which transfactors could be implicated based on published data.
Although the role of Fabp7 in fatty acid delivery during development is not clear, its involvement in cell growth and differentiation has been implicated based on its influence on cell morphology [3].
Interestingly, C5 has already been implicated, based on studies conducted in mice [ 12- 14], and it should therefore be considered an equally likely candidate.
How RA is initiated is unclear, but T-cell responses to self-antigens are implicated based on the strong linkage of RA to particular MHC alleles.
Antibody-dependent enhancement (ADE) has also been implicated, based on observations that re-infection by a different viral serotype increases the risk of severe dengue [ 31].
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However, local source emissions and valley transport may also implicate based on spatial distribution and altitudinal patterns.
In this review we present what is known about Myc from transgenics and conditional knockout models, and also include indirect evidence implicating Myc based on results from other studies.
These cells have been implicated in amyloidogenesis based on their close ultrastructural relationship with amyloid deposits [31], [32], phagocytic function [33], and their proteolytic enzymes [34].
In switchgrass two CAD genes (PviCAD1 and PviCAD2) have been identified and are implicated in lignification based on sequence identity, substrate specificity, and expression pattern [40].
Sro7p and Sro77p have been implicated in secretion based on genetic studies demonstrating decreased secretion of invertase and an accumulation of secretory vesicles in the absence of SRO7 and SRO77 [19].
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