Sentence examples for implicated as a proinflammatory from inspiring English sources
Substance P has been implicated as a proinflammatory mediator.
PAR1 has been implicated as a proinflammatory receptor in a thrombin-dependent model of crescentic glomerulonephritis [ 14].
Here, we have shown evidence that p38 MAPK and the α-isoform are upregulated in the pulmonary vessels of two different in vivo animal models of pulmonary hypertension and has been implicated as a proproliferative and proinflammatory pathway in the pulmonary artery fibroblast.
The proinflammatory cytokine TNF alpha has been implicated as a link between obesity and insulin resistance [ 46].
High mobility group box chromosomal protein 1 (HMGB1), a nuclear DNA-binding protein, proved recently to be a potent proinflammatory cytokine implicated as an important mediator of arthritis [ 1].
Homeostasis of proinflammatory and anti-inflammatory response in brain is shifted towards a proinflammatory state with age, so neuroinflammation has been implicated as an important etiological factor in several aging-related neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease [ 1– 3].
Although TLR4 has been implicated as the dominant proinflammatory receptor for HMGB1 [ 10], this receptor had only limited impact on the injurious host response during S. aureus pneumonia.
This [ 22] and other studies [ 23, 24] have further implicated PAR-1 as a proinflammatory receptor in acute as well as chronic lung injury.
To study whether the observed differences between PB and SF mDCs were related to DC maturation, as a control, we activated mDCs from PB with TSLP, previously shown to activate CD11c+ DCs and implicated to play a proinflammatory role in RA [ 25, 26].
TNFα and high mobility group box chromosomal protein 1 (HMGB1) are two potent proinflammatory cytokines implicated as important mediators of arthritis.
