It is implicated as a key player in different cellular processes including development, morphology, polarity, migration and tissue integrity [ 1].
Note that MyD88 has not only been implicated as a key player in defence mechanisms against microbial infection and inflammation, but also in several mouse tumourigenesis models.
One component of this tumor microenvironment, B-Cell Activating Factor (BAFF), has been implicated as a key player in this interaction.
The transcription factor STAT3 has been implicated as a key player in several features of malignant neoplasia including tumor cell survival, metastasis, and resistance to chemotherapy [ 11- 13].
Mitochondrial dysfunction, which has been implicated as a central player in aging theories for several decades, is among the nine recently characterized hallmarks of aging [ 1].
20 Given its apparent ability to activate PGC-1α and increase mitochondrial content in skeletal muscle, 20 SIRT1 has itself been implicated as a key player in metabolic health.
Along with brain cytokines, the placenta has been increasingly implicated as a key player in brain development, as well as in the fetal response to prenatal insults (Hsiao and Patterson 2012), and warrants further exploration in our model.
Overall, hnRNP K continues to emerge as an interesting protein, which through both mechanistic studies and expression profiling in different cancer types, has strongly been implicated as a key player of tumorigenesis.
RACK1 is also implicated as a key player in ovarian cancer [ 212], prostate cancer [ 188] and in cancers caused by pathogens such as human papillomavirus 16 (HPV 16) [ 213] and Helicobacter pylori [ 214].
A protein called protein kinase B (PKB, also called Akt) is frequently elevated in breast cancers and has been implicated as a key player in breast cancer development and progression.
