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Background: Enjoyment has been implicated as a determinant of physical activity among youth, but advances in understanding its importance have been limited by the use of measures that were not adequately validated.
The detection of HAdV infection in children after SCT has been implicated as a determinant of poor outcome but specific associations between HAdV species or individual HAdV types and disease are poorly understood.
In addition, CCR5 has been implicated as a determinant of cardiovascular risk in murine atherosclerosis models [23] and in patients undergoing hemodialysis [24].
Moreover, mTOR signaling has been implicated as a determinant of cell survival in response to DNA damage (Shen et al. 2007).
The TGFβ signalling pathway has been implicated as a determinant of pathogenicity and metastatic activity in tropical theileriosis: reduced TGFβ2 expression was measured for infected cells derived from an attenuated vaccine line and disease-resistant Sahiwal (Bos indicus) cattle (Chaussepied et al., 2010).
Folate one-carbon metabolism (FOCM) is strongly implicated as a determinant of susceptibility to NTDs since sub-optimal maternal folate status and/or elevated homocysteine are established risk factors, whereas periconceptional maternal folic acid supplementation can reduce the occurrence and recurrence of NTDs (7, 8).
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Abnormal dopaminergic transmission has been implicated as a risk determinant of HIV-1-associated neurocognitive disorders.
Native state topology has been implicated as a major determinant of protein-folding mechanisms.
The homeodomain has been implicated as a major determinant of biological specificity for the homeotic selector (HOM) genes.
CTCF has been implicated as a major determinant controlling HSV-1 latency.
However, no specific folate-related gene has yet been implicated as a major determinant of risk for NTDs.
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