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Although SNARE proteins can be sufficient to drive membrane fusion on their own [2], the precise temporal and spatial restrictions on exocytosis implicate the requirement of additional factors.
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This scenario implicates the requirement of factors that destabilize centriolar microtubules at the distal end prior to docking at the membrane.
In further support of multistep carcinogenesis, these DCIS models did not exhibit motile or invasive phenotypes, implicating the requirement for additional mutational events [ 10].
Similar scenarios can be envisaged for chromatin replication and DNA repair implicating the requirement for a dynamic organization also at transcriptionally silent locations.
Furthermore, over-expression of activated MEK1 in HepG2 enhances tumor growth in vivo and confers resistance to U0126-induced apoptosimplicatinging the requirement of MEK-MAPK activity for liver cancer cells to survive and tumor growth in vivo.
Furthermore, no measurable progeny were recovered from a host carrying a deletion in the PolI 5′→3′ exonuclease domain [ 7], clearly implicating the essential requirement of an active FEN for viral replication.
He questioned how work requirements "would implicate the 'core' objective of Medicaid: the provision of medical coverage to the needy". Able-bodied adults stretch the definition of "needy". Up until Obamacare, eligibility for Medicaid was restricted to families, children, pregnant women, and the disabled with incomes below the poverty line.
The steadily alternating and unpredictable requirements for industrial companies implicate the challenge to enhance production systems.
This would seem to implicate the factory.
G proteins of the Gq/11 type have been implicated [13,14] but the requirement is not absolute because activation by S1P or oxidized phospholipids is blocked by pertussis toxin, which inhibits Gi/o and not Gq/11 [8,15].
Clearly, the sheer activation of a caspase does not necessarily implicate its requirement for cell death.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com