Furthermore, members of the redox protein family, such as thioredoxin-1, have been reported to exert a positive effect on HIF-1α expression, 34, 35 implicating the essential role of redox protein in HIF-1α upregulation.
Furthermore, no measurable progeny were recovered from a host carrying a deletion in the PolI 5′→3′ exonuclease domain [ 7], clearly implicating the essential requirement of an active FEN for viral replication.
Although initial studies implicated the TPR domain as essential for interaction with both Hsp90 and Skp1 (Bansal et al, 2004), further analysis suggests that the N-terminal TPR domain mediates interactions with Skp1, whereas the central CS domain is responsible for the recruitment of Sgt1 to Hsp90 (Lee et al, 2004; Lingelbach and Kaplan, 2004; Catlett and Kaplan, 2006).
The above results strongly implicate an essential role of MIWI slicer activity in the regulation of mRNA stability beyond the two specific mRNAs shown in Figure 1.
The treaty says that Hong Kong can refuse to transfer a suspected criminal to the United States if giving up the person "implicates" the "defense, foreign affairs or essential public interest or policy" of the People's Republic of China.
For example, Hong Kong has the right to refuse to turn over a person when surrender implicates the "defense, foreign affairs or essential public interest or policy" of the PRC.
Hypoxia implicates the actin cytoskeleton through its essential roles in motility, invasion and proliferation.
Danto's thought experiments precisely identified the role of the evolution of observer aesthetic preferences over time in the genesis of art and aesthetic change, and they implicate an essential role for historical process in the determining what is art.
This variable penetrance probably reflects differences in the genetic backgrounds of the mice analyzed and also implicates BMP4 as the essential activator of lens induction.
Recently, a large body of evidence has shown that vesicle trafficking and exocytosis are essential in tumorigenesis, which implicates the Rab family proteins [ 11– 13].
