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A 2-fold cut-off was used to implicate significant changes in the abundance of differentially expressed proteins (DEPs) during grain development.
Moreover, our observations with respect to the cellular source of these cytokines also implicate significant changes in the airway macrophage population and their involvement in the pathophysiology of allergic airway responses in sheep.
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Cell enlargement implicates significant changes in the composition and structure of the cell wall.
This deficit becomes evident when examining the utility of current screening tools, such as those implicated in the angiogenic imbalance, where significant changes in sFlt-1 levels are only noted after 20 weeks of gestation [112].
Although ADAM10 has been implicated in Notch and β-catenin signaling, no significant changes in the respective target genes were observed in adult ADAM10 transgenic mice.
The adaptation of endothelial cells to cold induced significant changes in the abundance of cytoskeletal proteins that implicate diminished microtubular and actin networks, an expanded intermediate filament network and modified cell-cell and cell-extracellular matrix interactions.
Several other genes whose significant changes in expression correlate to morphology are implicated in metabolism and CNS development.
Heat-shock factor 1 (HSF1) and vitamin D receptor (VDR) have also been implicated CAF biology 39 40; however, we did not observe any significant changes in HSF1 and VDR expression under hypoxia (Fig EV5C).
Also, the genes that underwent significant changes were categorized into two groups: genes that have been implicated in alcoholic liver disease and genes that have not been tested for possible changes in expression.
Analysis of the expression pattern of receptors implicated in neuregulin or neurotrophin signaling (e.g., ErbB2, ErbB3, TrkB, TrkC) also revealed no significant changes in MAL-overexpressing Schwann cells (Table 1, B).
The PSIΔAB mutant results in significant changes in the AS patterns of ∼1,200 genes in the Drosophila brain, many of which have been implicated in the regulation of male courtship behavior.
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