Sentence examples for implicate primarily from inspiring English sources

The mechanisms underlying the negative regulation mediated by TGF-β1 implicate primarily genes that regulate the cell cycle, including the downregulation of growth-promoting transcription factors, such as c-Myc, ID1, and ID2 [ 22].

As in the Anderson case, Mr. Puckett was identified and implicated primarily by this evidence.

The human genome reveals more than 80 DD superfamily members, implicated primarily in the assembly of apoptotic and inflammatory complexes.

AVIL is implicated primarily by multi-copy amplifications (18% of cases), is in the shoulder of the CDK4/AGAP2 amplicon, and may play a role in the development of neuronal cells that form ganglia [39].

By contrast type II interferon (IFNγ), secreted by activated NK cells and T lymphocytes, has been implicated primarily in the activation of macrophages and has been demonstrated to be important for the protection of the host against intracellular pathogens such as Leishmania, Toxoplasma and Mycobacterium species [14].

Several intrinsic defects have been previously implicated, primarily those related to changes in the alveolar environment and the function of phagocytic cells [ 2].

IL-23 has been implicated primarily as a mediator of inflammatory bone loss via the activation of IL-17 production [ 26].

WRKY zinc-finger transcription factors, so named for the amino acid sequence WRKYGQK contained in the N-terminal region of their zinc finger motif, have been implicated primarily in defense responses of plants [ 9].

To date, this pathway has been implicated primarily in patterning the dorsoventral axis during development (that is, establishing the 'front' and 'back' of animals) (Petersen and Reddien, 2008; Moustakas and Heldin, 2009).

IL-23 has been implicated primarily in mediating inflammatory bone loss via the differentiation of Th17 cells and the production of pro-osteoclastogenic cytokines IL-17, RANKL and TNF [ 6].

To date, replicated associations between genetic variants associated with a few candidate genes, including IGF-1, ESR1, HSD3B1, and COMT and breast density have been observed, implicating primarily pathways that regulate steroid hormone synthesis and metabolism, hormone receptors and proliferative pathways, including the insulin-like growth factor pathway [ 6].