Sentence examples for implicate components of from inspiring English sources

The genetic variants that are associated with age-related macular degeneration strongly implicate components of the complement system, the loci associated with Crohn's disease point unambiguously to autophagy and interleukin-23-related pathways, and the height loci include genes encoding chromatin proteins and hedgehog signaling.

A number of studies have described agents that sensitize one or more breast cancer subtypes to TRAIL, the majority of which implicate components of the apoptosis regulatory machinery as the underlying causes of sensitization [ 22- 35].

There has been no evidence to date of yeast prion proteins being physically associated with any cellular structures, although there are several reports implicating components of the cytoskeleton in the process of [PSI+] prion generation and propagation in yeast [36] [38].

Postsynaptic glutamate receptor trafficking in particular has moved into the focus of interest because several independent lines of evidence have implicated components of the protein machinery that regulates AMPA- and NMDA-receptors at the synapse.

The cas genes have been implicated as components of a host defense system against invading foreign replicons [70].

Studies in laboratory animals have implicated many components of plant extracts as possible bioactive agents responsible for increasing endogenous testosterone levels and enhancing male sexual behavior.

We therefore directly analyzed the WNT pathway using a list of genes previously implicated as components of this pathway (http://www.stanford.edu/group/nusselab/cgi-bin/wnt/).

The link between inflammation and carcinogenesis is well known; experiments have implicated many components of the inflammatory cascade such as prostaglandin E2 and IL-6 as key players in tumor development, growth, and metastasis [ 37, 38].

Several Epc-N-containing proteins have been directly implicated as components of HAT complexes (e.g., NuA4 and TIP60 HATs2andATs aNuA3uA3 HATHAT), but intriguingly all proteins studied with PZPMs are associated with histone methylation and gene silencing.

However, although it has been shown that the basal membrane is involved in shaping the follicle and that the shape of the follicle may in turn impact StC flattening (Haigo and Bilder, 2011), there is currently no direct evidence implicating any components of the basement membrane in this process.

Taken together, these findings link hereditary forms of CP and implicate abnormalities of components of the dynamic cytoskeleton, process outgrowth, and protein trafficking with neuromotor dysfunction.