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Several lines of experimental evidence also implicate a function of ataxin-2 in RNA metabolism.
By contrast, biochemical studies in vertebrates implicate a function of RSK2 in feedback inhibition of the MAPK pathway (Romeo et al., 2012).
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In muscle, IL-1β increases MuRF1 and atrogin 1 expression implicating a function in atrophy [21 23].
Primary mammary gland tumors were observed in the MMTV-MUC1 lines but not in either the MMTV-MUC1ΔCT transgenic line or the wild-type control lines, implicating a function of MUC1-C in tumorigenicity in mammary tissue.
Based on previous genetic studies, which implicated a function of Drosophila RSK in motoneurons (Fischer et al., 2009b), we first determined the subcellular localization of RSK.
In mice, it has been colocalised with a calcium ATPase pump within the plasma membrane of distal tubular cells where evidence implicates a function related to calcium reabsorption (Cao et al, 2003).
Further, the expression of the sea star Cdx in the blastula stage, well before gastrulation has been initiated, implicates a function for Cdx that is not present in sea urchins.
Additionally, the presence of the conserved tripeptide motif Arg-Gly-Asp (RGD) on a solvent-exposed loop in the N-terminal Ig domain in the majority of human and some lower-primate PSGs implicates a function that involves integrin-related receptors [ 34].
CDKN1B rs7330 is a tag SNP with unknown function; however, its location in the 3′ untranslated region may implicate a regulatory function.
This result might implicate a specific function for CAS1 under CO2-limited conditions with regard to the production of sexual structures.
In view of the ability of Ena/VASP proteins to form functional tetramers [23], we can hypohesize that the phosphorylation of the two members of Ena/VASP family may implicate a similar function, and a similar regulatory pathway.
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