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Studies using cultured cells have described observations that implicate a factor that is produced by irradiated cells and transferred through the culture medium to nonirradiated cells (Little, 2000; Zhou et al, 2002).
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These findings implicate a varying seasonal factor such as UVB radiation and subsequent vitamin D synthesis in disease etiology.
However, a recent study has implicated a splicing factor SRPK2 in neuronal cell death through regulation of cell cycle progression [65].
Then multiple findings from various research fields can be combined to gauge whether a critical mass of evidence implicates a given factor.
Leukotrienes have been implicated in immune mediated bronchiolitis in animal and human models (22) and have also been implicated as a factor in lung fibrosis (23).
Indeed, studies in the Xenopus egg extract system implicated an additional factor, other than the APC/C, in the regulation of chromatid disjunction.
The decision to cut off poorer neighborhoods from private capital was implicated as a factor in the slow collapse of inner cities during the 1950s and 1960s.
The unusual structural qualities of these vessels are implicated as a factor underlying the high incidence of hemorrhage that occurs in the germinal matrix of prematurely born neonates.
Eosinophil infiltration of tissues is a hallmark of allergic responses and lung eosinophilia has been implicated as a factor of lung remodeling in asthma [14], [15].
IGF-1 has been implicated as a factor that may affect many steps in gene expression control, including cell proliferation, differentiation, and degradation processes.
IGF-1 has been implicated as a factor promoting hypertrophy in the adult animal.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com