Similarly, to implement the translational and rotational MCP, pixels in the interpolated reference frames are subsampled in ways such that the composite reference blocks are the rotated versions of the reference block.
Consequently, we felt the need to design a simpler informatics infrastructure that incorporated imaging but did not focus on it and that would be more easily implemented by translational research groups without special informatics expertise.
After excision, mature miRNAs or siRNAs are loaded onto the Argonaute (AGO) proteins, with other factors to assemble the RNA-induced silencing complex (RISC), guiding miRNA/siRNA to pair with specific RNA targets to implement the translational repression or silencing [ 5– 11].
We review important past and current approaches to drug development with an emphasis on implementing principles of translational research to achieve a rigorous conversion of knowledge from bench to bedside.
Overall, the following strategies need to be implemented to foster translational nephrology (Table 2).
While these topics are critical in demonstrating to stakeholders the value of implementing and sustaining coordinated care, more translational research and development of standardized evaluation tools are needed to facilitate adoption and evaluation of evidence-based programs in different settings.
PER proteins provide a good example of circadian rhythmicity in protein activity, implemented by post-translational modification.
Furthermore, control has been implemented at the transcriptional, translational and post-translational levels.
Here, we present a web-based application to fulfill this need by implementing two models, YR and W/S schemes, for the translational and rotational positioning of nucleosomes, respectively.
In this Editorial, I will discuss current difficulties in translational research as well as examples of good laboratory practice and guidelines that are being implemented to improve the translational potential of animal studies in the field of neuromuscular rare diseases.
