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Implementing such studies, however, is difficult.
However, a major factor in implementing such studies is that they require to be resourced adequately.
A difficulty in implementing such studies that the past common-garden environment needs to be very accurately replicated in the new experiment.
The rationale for using a twin design to identify risk and protective factors has long been argued, but the demands of implementing such studies has been formidable, including the length of time required to acquire an appropriate sample (see Breitner et al. 1993).
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If implemented, such studies could lead to improved natural barrier performance in future calculations.
In countries where cervical cancer screening is not widely implemented, such studies may not represent the general population and a non-invasive method acceptable to a representative sample of women is needed.
In summary, we have reviewed the recent literature on the use of GIS in exposure assessment for environmental epidemiology and described principles and applications of three core scientific disciplines needed, in our opinion, to successfully implement such studies: geospatial science, environmental science, and epidemiology.
The feasibility of implementing such a study protocol in primary health care setting was evaluated in this pilot study.
Future studies implementing such assays at greater numbers of loci and in more individuals, with more single molecules per individual, could provide mechanistic insights into loci influencing regional transmission rates in males.
Though we believe there is a great need for research like this from developing countries, we also acknowledge that there will be challenges in implementing such an ambitious cohort study.
However, one study implementing such higher HbA1c targets (8%% or less as proposed by the American Geriatrics Society) in a poorly controlled population resulted in fewer overall hyperglycaemic episodes, but more hypoglycaemic episodes requiring emergency room attendance during the early implementation phase [ 38].
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