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To the extent that drug interactions with genotype impact the safety [ 47] or efficacy of AD treatments [ 48- 50], ethnogenetic differences within trial samples should be considered when implementing multinational trials.
These and other factors could introduce heterogeneity into AD trial samples and should be considered when implementing multinational trials.
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Secondary analysis of data were from two multinational trials (n=629; 765).
Although recommendations for conducting economic evaluations have been widely disseminated, relatively little guidance has been given for conducting economic evaluations alongside clinical trials, particularly multinational trials.
The increase in the number of multi-centre and multinational trials is also encouraging.
The majority of trials were multinational trials.
Multinational trials enable expedited recruitment and are necessary to secure multinational regulatory registration and eventual patient access [ 5].
Multinational trials that had trial sites in India and South Africa were selected for this study.
Pharmaceutical companies commonly perform large multinational trials, while non-industry trials are more often initiated and conducted by local investigators.
In addition, the Japanese trials had higher patient drop-out rates and more missing data than the multinational trials.
This may also explain why CRCs involved in multinational trials play a greater role in query resolution and audit.
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