Both the sampling and time issues were possibly due to the relative difficulty of implementing randomized, controlled trials in real clinical settings [ 54].
Finally, the article highlights the need for future studies, prospective and interventional in nature, while underlying challenges of the classic approach implementing randomized, controlled trials that may prove inept in this field.
The enthusiastic preliminary results from animal hypothermia studies could not be satisfyingly reproduced when implemented in human controlled trials, shifting the focus on the possible side effects of hypothermia.
It gives limited help with the 'how do we implement it?' question, which controlled trials are not designed to answer.
The network will establish the infrastructure necessary to initiate, implement, and evaluate randomized controlled trials in community settings and health care facilities among pregnant women, newborns, infants, and children to the age of 3 years.
Implementing a randomized, controlled trial in donors has led to many challenges, which are addressed below.
Once randomized, controlled trials will have provided the clinicians with the best transfusion strategies, these will have to be implemented.
The review covered only carefully controlled trials.
Randomized controlled trials (RCTs).
Controlled Trials ISRCTN09968140.
For example, the Zambia team plans a randomized roll-out of its intervention through a step-wedge design [ 2] and Tanzania is implementing a cluster randomized controlled trial [ 3].
