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Implementing a genomic breeding scheme would generate large additional costs.
Another important question is the level of predictive value that is to be targeted before implementing a genomic profile.
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In order to estimate separate molecular clock parameters for each partition whilst simultaneously minimising estimation variance, we implemented a genomic partition model in BEAST v1.5.4 [ 21].
To illustrate this, for W1 1, an extra annual cost of €260 000 was more effective if used to implement a genomic breeding scheme than to improve the efficiency of the pBLUP scheme when the genotyping costs were low (regardless of the phenotyping cost of sibs), or when genotyping costs were medium and phenotyping costs of sibs were high.
We implemented a Bayesian genomic cline model that incorporates uncertainty in genotypic state inherent in next-generation sequence data [ 43], but is otherwise identical to the model described by [ 52].
In designing, developing, and implementing a national CDS infrastructure for genomic and personalized medicine, it will be important to leverage available resources.
(ii) implement an object-relational genomic catalog storing viral genome information correcting existing discrepacies.
To identify putative RNA structures associated with the coding region for ribosomal protein S15 (rpsO), we implemented a computational pipeline, GAISR (Genomic Analysis for Illuminating Structured RNA, Figure 2) for de novo ncRNA discovery and candidate refinement.
When implementing long-term genomic selection, genomic control of inbreeding is essential to reduce the considerable hitch-hiking effects that are associated with genomic selection, regardless of the prediction model used.
A major challenge to implementing genomic medicine is integration of genomic information into the electronic health record (EHR) [ 8].
In conclusion, we found that results for the accuracy of GEBV further support the notion that genomic evaluation using high-density genotypes imputed with high accuracy for selection candidates is a feasible method to implement a cost-efficient design for genomic selection in swine.
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