Initially, we planned to implement a crossover arm for the CG in order to achieve the sample size as early as possible [ 28].
This was a randomized, double-blind, 22-week study that implemented a crossover design to compare a low-dose green coffee extract, a high-dose green coffee extract, and a placebo.
They implemented a crossover research design in a freshman-level biology majors course (eight sections, 629 students participated in the study): in one treatment, students were shown the bar graph before peer discussion, and in the other treatment, they were not.
Whilst recently published reports have examined the effects of this ergogenic strategy on continuous bout HIE (Bellinger et al. 2012; Sale et al. 2011), no study to date has, to the authors knowledge, investigated its effects on intermittent HIE or implemented a crossover design to account for individual variability.
By implementing a case-crossover design, we were able to reduce or eliminate both known and unknown confounders by cases serving as their own controls.
We are currently implementing a 3-month randomized crossover trial comparing brown rice to white rice meals (breakfast and lunch, 6 days per week) on biomarkers of diabetes risk among adults at high risk for developing diabetes in a cafeteria setting at MDRF.
Because we implemented a case-crossover design, each case served as his or her own control and confounding by between-person differences and covariates that do not change within individuals during the study period (sex, race) was eliminated (Carracedo-Martínez et al. 2010).
This study used a nontraditional study design that implemented a 2-period crossover design within 1 menstrual cycle.
In addition, REDHORSE implements a custom recombination detection algorithm that makes use of sequence information and genomic positions to accurately detect crossovers.
First, we implemented an alternative tree-based GE crossover strategy as previously described [ 46, 47].
