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Implementation: Gene expression analysis was implemented using the free software Bioconductor version 2.11.1.

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The G4M procedure was implemented using the free and open source software GRASS GIS16 version 6.4 (GRASS Development Team 2010), hereinafter referred to as GRASS.

A prototype has been implemented using the AGG software tool.

Machine classification algorithms were implemented using the Weka software package (v3.6) [28].

This was implemented using the R software.

All classifiers were implemented using the Weka software package [ 70].

This procedure (ZO) is implemented using the StOCNET software package.

Quadratic regression fits were implemented using the SigmaPlot software package.

Linear programming is implemented using the GNU Linear Programming Kit software [ 55].

It is implemented using the frame-based Software Platform for Agent and Knowledge Management (SPAK).

Statistical analyses were implemented using the R statistical software.

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