A new function, a weighted correlation coefficient with coherence constraints (73), was thus introduced to replace linear, nonweighted cross-correlation, and implemented in the refinement program FREALIGN (74).
Several instantiations of the mesher level class can be stacked and tied together to implement the whole refinement process.
To resolve the issue in flux calculation, this work implemented the refinement/coarsening algorithms into a collocated solver to avoid tedious interpolations in solving the momentum equations.
By implementing the adapted LO-refinement theory with improved codes for efficient computation, our LO-refinement algorithm will provide an alternative solution in real space to deal with the conformational flexibility of macromolecular complexes for single particle analysis.
The database is now available at FML implements the software and refinements the system.
In this work, we propose a functional programming based framework for modeling and simulating LIP, and implement the semantics of various refinement steps in the programming model, so we can validate the LIP model against the original system within this functional programming framework.
As mentioned, MULTICOM-REFINE, MUProt and MULTICOM all focus on model combination and refinement, and all implement the global local model combination algorithm just described.
Care was taken to implement the 3 Rs rule (replacement, reduction, and refinement) both to reduce the number of animals used and the suffering during the experiments.
The second refinement is an enhanced parameter estimator that uses a numerical integrator that implements the RKF45 method [ 28].
It should be noted that it is customary to work within the 'riding' approximation, which results in the much simplified chain rule implemented in all refinement programs, including Olex2.
Two natural parallelization strategies (best-first and simple hill-climbing) were implemented for the iterative refinement stage.
