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Angus et al. [ 1] performed a large-scale, multi-centre epidemiological study in which they implemented the identification of patients with severe sepsis using an ICD-9-based algorithm that required evidence of both an infection and new-onset organ dysfunction during a single hospitalization, thereafter described as the Angus implementation coding scheme.
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Implementing the identification technique using a dedicated hardware like field programmable gate arrays (FPGA) could be useful to achieve smart units.
In the context of the linlog metabolic modeling framework, we implement the identification method by an Expectation-Maximization (EM) algorithm and by a simpler direct numerical optimization method.
EBC implemented the iterative identification procedure, performed the computations and drafted the manuscript.
MT conceived and implemented the CD identification tool and helped to draft the manuscript.
The automated patch clamp was implemented with the identification approach successfully.
The proposed approach has been successfully implemented for the identification of the single-base mutant sequences in the human KRAS gene with a detection limit of 1.8 pM.
A series of validation tests were designed and implemented in the identification of four inhibitors of human DDAH-1 that were unknown prior to the screen.
This approach was successfully implemented for the identification of performance-enhancing molecules that should be prohibited in sports [50], and for predicting multi-target bioactivities of potential polypharmacological compounds for treatment of neurological diseases [51].
The proposed approach has been successfully implemented for the identification of single base mutation at the −28 position in human β-globin gene with a detection limit of 0.5 fM, demonstrating that this method provides a highly specific, sensitive and cost-efficient approach for point mutation detection.
A similar approach was implemented for the identification of soybean HPts and RRs.
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CEO of Professional Science Editing for Scientists @ prosciediting.com