Costs reflect the interventions as implemented in the trial.
Models of interest were implemented in the trial simulator TS2 version 2.1.2 (Pharsight, Mountain View, CA).
Individualized health coaching by telephony, as implemented in the trial was unable to achieve majority of the disease management clinical measures.
Furthermore, the MLU intervention described in the trial protocol and implemented in the trial itself for women allocated to the MLU arm can be regarded as standard practice for MLU care in the two study sites, since the relevant procedures were established in the context of the MidU trial.
As independent interpretation with exact duplication of reading conditions for multiple radiologists are not implemented in the trial, for the purposes of our analyses we assume that the paired arms of the study for 2D alone (Arm A plus B) and 2D + 3D (Arm C plus D) constitute sufficiently similar reading conditions to be considered double readings.
161 Although each of the many types of monitoring methods has its limitations, 157 158 adherence data can help to inform the statistical analysis (Item 20c), trial interpretation, and choice of appropriate adherence strategies to implement in the trial as it progresses or in future trials and clinical practice.
They were properly implemented in the CZP trials in terms of patient and investigator training, timing of assessments, linguistic validations, and pre-specification of analysis in the statistical analysis plan.
This strategy was posteriorly implemented in the CUPID trial (see below).
The ASP program was implemented in the latter trial stage; however, it drew heavily from the education and skills-building already implemented with all participants in the pre-trial and early-trial stages.
68 The most favorable dosing regimen that allowed differentiation of antitumor effect from drug-induced thrombocytopenia was selected and implemented in the FIH trial.
The present commentary deals with some of the recent controversies related to use of a low tidal volume strategy, as implemented in the ARDSNet trial, which has proved successful in reducing mortality rates in patients with acute respiratory distress syndrome.
