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We believe the analysis and evaluation presented here can facilitate the development of practical guidance that can be implemented in regulatory programmes requiring this test.
Other attempts to score study reliability were developed by industry and other institutions [23]; however, to our knowledge they like most other methods were not implemented in regulatory guidance documents.
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The policy actions (regulatory drivers) already implemented in a regulatory push by the European Commission and the ensuing steps towards achieving the EU framework for LNG as an alternative ship fuel are summarized in a communication entitled "Actions towards a comprehensive EU framework on LNG for shipping" (European Commission (2013)).
Such cooperation is facilitated by the common standards of ICH coupled with regulatory systems aligned with international practices implemented in their regulatory processes.
The dynamical properties of the model indicate that the biological dynamical sequence is robustly implemented in the regulatory network, with the biological stationary state G1 corresponding to the dominant attractor in state space, and with the biological regulatory sequence being a strongly attractive trajectory.
The VICH phase I guidance document (VICH 2000) informs environmental risk assessment of veterinary medicines and has been implemented in the regulatory scheme in the European Union, United States, Japan, and Australia (de Knecht et al. 2009).
It can also be implemented in a mixed regulatory network which blends signaling and gene nodes in the same interaction graph (cf. Fig. 1 e)).
The newly developed guidelines will be implemented in cooperation with governmental regulatory bodies.
This study has provided an overview of regulatory measures implemented in the European Union targeting drug prices.
Table 1 provides an overview of policy options in regulated pharmaceutical markets and Table 2 provides an overview of regulatory policies implemented in each of the study countries.
The presented application clearly illustrates these basic residual-QSAR properties, implemented in close agreement with the regulatory OECD principles on multi-regression models.
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