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As these recent estimators are fundamentally informed by the same underlying parameters as the hitchhiking mapping approach implemented in genomic scans, I here ask whether published results from both approaches are consistent with one another.
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Availability: MCFDR is implemented in the Genomic HyperBrowser (http://hyperbrowser.uio.no/mcfdr), a web-based system for genome analysis.
Hierarchical clustering was done by using the clustering analysis implemented in the Genomic Workbench software.
Two alternative algorithms were presented that can be implemented in various genomic prediction models for fast computing of SNP effects.
Data were assessed with a series of quality control metrics and analysed using an aberration detection algorithm (ADM2) [ 31] implemented in the Genomic Workbench software package (Agilent).
We used the de novo method implemented in CLC Genomic Workbench v.7.0.2 to generate assemblies for each species, using the default settings.
We used one-way ANOVA implemented in Partek Genomic suite 6.2 beta to generate a list of differentially expressed genes under each condition.
Normalization of probe signal intensity levels across arrays was performed using the GC robust multichip average algorithm implemented in Partek Genomic suite 6.2 beta.
Our methods are implemented in GSNAP (Genomic Short-read Nucleotide Alignment Program), which can align both single- and paired-end reads as short as 14 nt and of arbitrarily long length.
The molecular subclasses, S1 (TGF- β/WNT activation), S2 (MYC/AKT activation, AFP positivity) and S3 (preserved hepatocyte function), were determined by using the nearest template prediction algorithm (Hoshida, 2010) implemented in GenePattern genomic analysis toolkit (www.broadinstitute.org/genepattern).org/genepattern
Our methods are implemented in GSNAP (Genomic Short-read Nucleotide Alignment Program), which can align single- and paired-end reads as short as 14 nt and as long as desired.
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