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Integrating the findings from the qualitative interviews with the modelling thus identified the components of the screening test intervention that could be implemented in a trial from a service perspective.
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Briefly, all these extra questions and all the questionnaires for the intervention have been satisfactorily implemented in a pilot trial, with a similar sample of children and parents during the last edition of the Nereu programme.
The following five concepts were identified as being important to the CHC patients, easily implemented in a clinical trial and sensitive to change over time: 1) depression/anxiety; 2) fatigue; 3) flu-like symptoms; 4) cognitive function; and 5) insomnia.
The CKD273 classifier is currently been implemented in a Multicentric European Trial, called PRIORITY where 3280 patients with diabetes type 2 are employed.
These findings will be implemented in a future international trial.
The intervention was then implemented in a cluster randomised trial with 104 GP practices randomised, (the protocol has been reported in Gulliford et al. [ 23]).
Although impractical for the purposes of this pilot, blinding should be implemented in a large-scale trial, to help avoid the potential for bias [ 10].
We define MVHT as the extent to which a homeopathic intervention and the main measure of its outcome, as implemented in a randomised controlled trial (RCT), reflect 'state-of-the-art' homeopathic practice.
This study was designed to evaluate the longitudinal reproducibility of the DLW method using 2 protocols developed and implemented in a multicenter clinical trial-the Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy (CALERIE).
This design was implemented in a recently completed clinical trial of simtuzumab (RAINIER study) and provides a useful case study for designing future confirmatory clinical trials of novel targeted therapies.
Tomosynthesis-based screening was successfully implemented in a large prospective screening trial.
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