"We have reviewed each of these failures and implemented corrections as appropriate.
For the latter, violations may pertain to prioritization or pre-screening algorithms, to the actual epistasis modeling and testing, as well as to the implemented corrections for multiple testing.
Until such a signature is identified and validated, it will remain difficult to implement correction strategies for individual patients.
Within this field of prediction of disability-related problems, clinical investigations should attempt to detect alterations and implement correction measures.
The Stata and R code can be found at along with tutorials on using the code (including survival time data, multivariable models, joint and conditional models), discussions of how to interpret decision curves, and code to implement correction for overfit by repeated 10-fold cross-validation.
Cusp relies heavily on "local staff" training in the science of safety how to identify problems, report them, measure them, plan and implement corrections, and measure again.
To make this manual correction process possible in a reasonable time, a number of VBA macros were written for the Excel index file to display the speed profile for individual segments, flag segments with unusually high or low energy consumption and automate the process of recording and implementing corrections.
To implement corrections for multiple comparisons at the P < 0.05 level, we used Monte Carlo simulations implemented in AFNI's AlphaSim to identify the required cluster-size threshold, given the voxel-wise probability and the volume in the statistical map (see below) separately for each of the tests in a conjunction.
Cawley (2004), Cawley et al. (2007), Lakdawalla and Philipson (2007), and Baum and Chou (2011) have all implemented the correction, but none of these authors have found that the correction changes their results in a meaningful way.
In this table we have implemented the correction model only to the active light spots.
An automated detection was implemented and correction was performed with interpolated values.
