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We implemented a genome database for K. pneumoniae, BIGSdb-Kp, and defined 694 genomic loci suitable for genotyping as well as loci associated with virulence and antimicrobial drug resistance.
The Medical College of Wisconsin and Children's Hospital of Wisconsin have implemented a genome sequencing program to which clinicians can nominate patients who remain undiagnosed after appropriate clinical evaluation and testing.
Concomitant with this new reference sequence release, SGD has also implemented a genome versioning system to clearly distinguish each genome sequence change since the original 1996 assembly (22) (v1) to the most recent (v64).
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For such purposes, we have also implemented a genome-alignment module.
Therefore, we have implemented a genome-guided strategy for clustering the mapped ESTs similar to other published studies (e.g., [ 12, 16]).
We have designed and implemented a genome-wide SNP array tailored for deeper capture of variation in loci of high priority in transplantation.
To compensate for this deficiency, we implemented a genome-wide noncomplementation screen for quantitative trait alleles using the yeast deletion collection.
We developed and implemented a genome-wide analytic approach that integrates transcriptional gene expression and miRNA expression to identify robust SNP associations with IC50 (drug concentration required to inhibit 50% of cellular growth) in response to carboplatin or cisplatin treatment (evaluated separately).
The time was right to carefully consider implementing a genome browser as a way to integrate genomic sequence features with the existing genetic and physical information at MaizeGDB.
We identified TRPV6 as a putative target of local selection by implementing a genome scan based on two summary statistics of the sequence data (Figure S1), analogous to that performed previously [6].
Because maize researchers have a wide range of research interests, we decided to implement a genome browser that could be adapted to address general research questions.
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