More importantly, there were differences between implementation sample and regional population regarding age.
The second attribute, which differed between implementation sample and population, was the prognostic stage (UICC; Figure 3).
The frequency distribution was bell-shaped in the regional population, but skewed in the implementation sample, with patients missing above the age of 70 years.
Following theory and modeling, this study contains the exploratory trial as a next step before the randomised clinical trial (RCT) answering three questions: (1) Are there differences between implementation sample and general population?
In the implementation sample only 18 out of 170 patients were ⩾70 years of age (11%; C.I. 6.8 16.1%), whereas in the regional population this proportion was almost three times larger, 137 out of 509 (27%, C.I. 22.9 30.6).
Our implementation periodically samples both Z_RLE and the default strategy on data blocks to determine the optimal method.
In its simplest implementation, protein samples are extracted from their biological source, subjected to enzymatic digestion and the resulting peptide mixtures are finally analyzed by LC-MS/MS.
Availability and implementation: The sampler has been implemented as a publicly available BEAST 2 package that is distributed under version 3 of the GNU General Public License at http://compevol.github.io/MultiTypeTree.
