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However, there are major hurdles to overcome before the implementation of these tests in clinical laboratories with reference to type of test, technology and equipment to be employed, and issues such as cost effectiveness, accuracy, reproducibility, personnel training, reimbursement by third-party payers, and intellectual property.
The second aim was to use these estimates to determine guidelines for the optimal implementation of these tests, either singly or in combination, to maximise the accuracy of diagnosis of TB in live badgers.
The reproducibility and standardization of the serum assays are serious limitations to the broad implementation of these tests.
If the functionality and the implementation of these tests have changed since then, we suggest that the authors clearly list these new improved items in the paper for more clarification.
A critical assessment of how complicated invasion histories, including founder events and genetic admixture, might impact the ability of these methods to detect loci under very recent divergent selection has not yet been conducted, but these processes could represent an impediment to the successful implementation of these tests in some invasive species.
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The expertise of the educators and researchers from the Medical Council of Canada, the National Board of Medical Examiners and the General Medical Council in conducting the standardized MCQ exams and OSCE patient encounter assessments would be beneficial to ease the implementation of these testing formats.
In general, we recommend that at least one test from each category (that is, one burden test assuming all alleles impact the trait in the same direction and one burden test allowing for alleles with opposite directions of effect in each gene) should be considered and that variable threshold implementations of these tests should be used.
The proposed trial aims to test the value and optimal implementation of these new tests, standalone and in combination, to derive parameters for a new personalized strategy for diagnosis and treatment of patients with (suspected) recurrent DTC.
The implementation of these national tests led to a change in the distribution of generalists/specialists (targeted at 50/50) in the choice of junior doctors' posts, which had been less than 40% for general practitioners [ 17].
ZY carried out the design and implementation of the test platform and drafted the manuscript.
The implementation of the test cases presented challenges related to the gap between the Lua API B model and the Lua API standard implementation.
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